Nanoparticle injections to cure Osteoarthritis!

Q.  Injecting which particles into a joint following injury can suppress inflammation?
- Published on 30 Sep 16

a. Neural
b. Radioactive
c. Nano
d. Atom

ANSWER: Nano
 
Nanoparticle injections to cure Osteoarthritis!Injecting nanoparticles into a joint immediately after an injury may suppress inflammation, reduce the destruction of the cartilage and lower the risks associated with osteoarthritis, according to scientists.
Considering that there’s really no treatment and even when we inject steroids into the arthritic joint, the drug only remains for up to a few hours and then it’s cleared, this is a massive advancement
  • Nanoparticles remain in the joint longer
  • They also help prevent cartilage degeneration
  • Osteoarthritic patients also suffer early injuries such as torn meniscus or anterior cruciate ligament injury
  • Drugs such as ibuprofen are taken and the pain gets worse, as injections of steroids provide pain relief, but effects are short lived
  • Nanoparticles were injected shortly after the injury and within 24 hours, nanoparticles were at work taming inflammation in the joint
  • Unlike steroids which quickly clear, the nanoparticles remain in cartilage cells in joints for weeks
  • Nanoparticles are 10 times smaller than RBC which helps them to penetrate deeply into tissues.
  • Particles carry a peptide derived from natural protein melittin modified to enable it to bind a molecule called small interfering RNA (siRNA).
  • siRNA then gets delivered by the melittin into the damaged joint, interfering with cell inflammation
  • Nanoparticles were injected directly into the joint, and due to their size, they easily penetrate into the cartilage to enter injured cells
  • Nanoparticles have previously been delivered through the bloodstream and inhibit inflammation in the model of rheumatoid arthritis
  • In this study, they were locally injected into the joint and given the chance to penetrate the injured cartilage
  • Nanoparticles, if given soon after joint injuries occur, could help maintain cartilage viability and prevent progression to osteoarthritis.
  • Inflammatory molecule targeted not only causes problems after an injury, but it is also responsible for inflammation in advanced cases of osteoarthritis

Related Content

➨ Post your comment / Share knowledge


Enter the code shown above:

(Note: If you cannot read the numbers in the above image, reload the page to generate a new one.)
▲