Researchers identify gene variation implicated in obesity
Q. Researchers have identified a single variation in a gene that influence obesity through lowering of protein levels that make us feel full. Name the protein.- Published on 02 Nov 15a. BCNF
b. BDNF
c. BTNF
d. None of the above
ANSWER: BDNF
NICHD Researchers have found that single variation in BDNF/ Brain Derived Neurotropic Factor predisposes persons to obesity by lowering levels of BDNF, a protein regulator of appetite in the human brain. Researchers also found that raising BDNF protein levels may offer a therapeutic strategy for people with the genetic variation, which tends to occur more frequently in African Americans and Hispanics, than in non-Hispanic Caucasians. BDNF plays a role in feeling of satiation and they have identified an area of the gene where single change has lowered BDNF levels within the hypothalamus. Genetic changes are a variation that take place in the general population. There are 2 copies, or alleles, of each gene, inheriting one copy from each parent. Overall, the study suggests that the C allele of the BDNF gene may be linked to obesity in people.
