Study published indicates glioblastoma cells act as tumour promoters

Q.  Scientists have uncovered which cell acts as a tumour promoter through beta-catenin, a tumour promoting pathway?
- Published on 17 May 16

a. IGFBO2
b. IGFBP2
c. IGFBJ2
d. None of the above

ANSWER: IGFBP2
 
In a study published in Neuro-Oncology’s recent issue, IISC ad NIMHANS scientists have found the answer to a puzzle surrounding the most common form of brain tumour- Glioblastoma.
  • Glioblastoma cells, IGFBP2 acts as a tumor promoter through a well known tumor promoting pathway, beta-catenin. Like insulin. this is a binding protein.
  • IGFBP2 is one of the proteins presented in extracellular or outside cell fluids. It was found higher IGFBP2 levels led to inactivation of another protein - GSK3. Inactivation of GSK3 impairs the degradation of beta catenin inside the cell.
  • Beta catenin can now easily transport to the nucleus and induce production of new proteins that instruct the tumor cells to proliferate faster than normal, and start invading other tissues.

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