Identify the correct sequence to make a coherent paragraph:

A. A lot of work waits to be done to standardize protocols, define malpractice, and codify patient rights.
B. Given the impoverishing nature of costs and the poorly evolved state of health insurance, there is an urgent need for comprehensive regulation.
C. The annual health expenditure in India is estimated by the Insurance Regulatory and Development Authority to be in the region of Rs.300,000 crore.
D. Nearly a third of this goes towards hospital-related procedures and treatment, and the rest for outpatient and domiciliary treatment, medicines, investigations, and so on. Much of this is spent out-of-pocket.